Deserto del Mojave, 1908. Tre killer vengono uccisi presso una stazione ferroviaria da un misterioso straniero soprannominato "Armonica" per l'abitudine di vagare suonando continuamente questo strumento musicale. I tre sono uomini di Frank, spietato assassino al soldo di Morton. Costui un moribondo industriale ferroviario ammalato...

After a band of Indians kill a group of soldiers, Sergeant Hook captures them and their leader Nanches. Among the prisoners is Nanches' son and the boy's white mother captured by them nine years earlier. Hook's assignment is to escort the mother and son to the woman's husband. Traveling by stagecoach they learn that Nanches has escaped and it's not long before he and his warriors show up intent on reclaiming the boy.

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Relegated to B-movie status by the mid-1930s, the western was regenerated most prominently by John Ford's Stagecoach in 1939. Ford and screenwriter Dudley Nichols artfully balanced the genre's standard action with the character studies and quality production values of prestigious 1930s films. In the microcosm of the stagecoach, the confrontation between "civilization" and "savagery," Western future and Eastern past, is played out among characters journeying through hostile Apache territory, with honor-bound outlaw Ringo fighting valiantly for a society that shuns him. Though not the top-billed player, and then a B-movie actor, John Wayne as Ringo became the star hero from the moment that Ford introduces him with a rare kinetic flourish. Ford here introduced his signature Western setting of Monument Valley, lending Stagecoach a realism that set it apart from studio-bound films; and his deep focus interiors preceded Citizen Kane by two years. A critical and commercial hit, Stagecoach helped spearhead the revival of the Western as a viable A-feature, and it turned Wayne into an A-list star. When he made Citizen Kane, Orson Welles claimed that he learned everything about directing movies from watching Stagecoach more than 40 times.

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Ethan Edwards, returned from the Civil War to the Texas ranch of his brother, hopes to find a home with his family and to be near the woman he obviously but secretly loves. But a Comanche raid destroys these plans, and Ethan sets out, along with his 1/8 Indian nephew Martin, on a years-long journey to find the niece kidnapped by the Indians under Chief Scar. But as the quest goes on, Martin begins to realize that his uncle's hatred for the Indians is beginning to spill over onto his now-assimilated niece. Martin becomes uncertain whether Ethan plans to rescue Debbie...or kill her.

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Hired gunman Cole Thornton turns down a job with Bart Jason as it would mean having to fight an old sheriff friend. Some months later he finds out the lawman is on the bottle and a top gunfighter is heading his way to help Jason. Along with young Mississippi, handy with a knife and now armed with a diabolical shotgun, Cole returns to help.

Robert Aldrich returns to the western-spoof genre he'd previously explored in Four for Texas with The Frisco Kid. Gene Wilder plays Polish rabbi Avram Belinsky, who intends to set up a congregation in San Francisco. Eminently unsuited for life in the Old West, poor Avram is victimized by everyone with whom he comes in contact. Salvation arrives in the unlikely form of taciturn bank robber Tommy (Harrison Ford). Incredibly, Tommy takes a liking to the feckless Avram, and together the two men embark on a series of seriocomic adventures.

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A small-town sheriff in the American West enlists the help of a cripple, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.

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